Scientists have made a groundbreaking discovery in the field of reproductive biology, claiming to have "rejuvenated" human eggs by reversing an age-related defect that causes genetic errors in embryos. This breakthrough could potentially revolutionize IVF success rates for older women, who are often plagued by declining egg quality and increased risk of chromosome disorders such as Down's syndrome.
According to researchers at Ovo Labs, the age-related defect is caused by a decline in a protein called Shugoshin 1, which acts as a "glue" to hold chromosome pairs together. When this protein declines with age, it leads to premature separation of chromosome pairs, resulting in embryos with too many or too few chromosomes.
In an experiment using eggs donated by fertility patients, the researchers found that microinjections of Shugoshin 1 nearly halved the number of eggs showing the defect, from 53% in control eggs to just 29%. The results were particularly promising when looking at eggs from women over 35 years old, with a similar trend observed (65% compared with 44%).
The approach is simple yet innovative: by supplementing eggs with Shugoshin 1, researchers aim to restore the younger situation and improve egg quality. However, it's essential to note that this technology would not extend fertility beyond menopause, when the egg reserve runs out.
While the results are encouraging, further trials are needed to confirm the findings and ensure the approach is safe for human use. The team at Ovo Labs is already in discussions with regulators about a clinical trial, but an important question remains: will the apparent improvements in egg quality translate into fewer genetic errors in embryos?
Experts describe the discovery as "really promising," and it offers new hope to women struggling with declining fertility due to age. If confirmed, this approach could potentially improve IVF success rates for older women, allowing them to conceive within a single IVF cycle – rather than having to try multiple times.
The significance of this breakthrough lies in its potential to address the primary cause of IVF failure and miscarriage in older women: declining egg quality. With millions of women around the world struggling with infertility due to age, this discovery offers a beacon of hope for those seeking reproductive solutions.
According to researchers at Ovo Labs, the age-related defect is caused by a decline in a protein called Shugoshin 1, which acts as a "glue" to hold chromosome pairs together. When this protein declines with age, it leads to premature separation of chromosome pairs, resulting in embryos with too many or too few chromosomes.
In an experiment using eggs donated by fertility patients, the researchers found that microinjections of Shugoshin 1 nearly halved the number of eggs showing the defect, from 53% in control eggs to just 29%. The results were particularly promising when looking at eggs from women over 35 years old, with a similar trend observed (65% compared with 44%).
The approach is simple yet innovative: by supplementing eggs with Shugoshin 1, researchers aim to restore the younger situation and improve egg quality. However, it's essential to note that this technology would not extend fertility beyond menopause, when the egg reserve runs out.
While the results are encouraging, further trials are needed to confirm the findings and ensure the approach is safe for human use. The team at Ovo Labs is already in discussions with regulators about a clinical trial, but an important question remains: will the apparent improvements in egg quality translate into fewer genetic errors in embryos?
Experts describe the discovery as "really promising," and it offers new hope to women struggling with declining fertility due to age. If confirmed, this approach could potentially improve IVF success rates for older women, allowing them to conceive within a single IVF cycle – rather than having to try multiple times.
The significance of this breakthrough lies in its potential to address the primary cause of IVF failure and miscarriage in older women: declining egg quality. With millions of women around the world struggling with infertility due to age, this discovery offers a beacon of hope for those seeking reproductive solutions.
This is insane! The idea that scientists can basically "rejuvenate" human eggs by fixing an age-related defect sounds like something straight outta sci-fi 
. But seriously, if it works, it could be a game-changer for women struggling with declining fertility due to age. I mean, think about it - no more trying multiple IVF cycles, no more false hopes... just actual babies 
. And the fact that this tech doesn't aim to extend menopause is super responsible, because let's face it, that's not something you can change 
. But what really excites me is the potential for this to improve IVF success rates and reduce genetic errors in embryos... it's like a whole new world of possibilities opens up 
!
This is so cool! I mean, can you even imagine being able to have kids later in life without all the stress and uncertainty? 
Like, 35 isn't old at all! 
The fact that scientists found a way to basically 'rejuvenate' eggs by fixing this one protein defect is mind-blowing. I'm definitely rooting for them to make it through further trials and get this tech on the market ASAP! 
Still, the optimism is real – who knows what the future holds?
so to see actual science behind it is just wow... if they can actually make a diff in egg quality that would be amazing for women trying ivf at older ages... like, 35+ who are just getting shut down left and right 
this could literally change lives 
]
! I mean, can you imagine being able to have kids without all the stress and uncertainty that comes with IVF? It's like, a total game-changer for women who are struggling with fertility due to age. And it's not just about being able to conceive, but also about reducing the risk of genetic errors in embryos which is literally a huge deal 
. But yeah, let's keep an eye on those further trials to make sure it's safe for human use 
And it's all because of some protein called Shugoshin 1 that just kinda... stops working as we get older 
. Anyway, it's good to see someone finally doing something about this stuff 
! I can imagine it would be life-changing for women struggling with declining fertility due to age... It's all about finding ways to improve IVF success rates and give people more hope 
. The fact that this technology wouldn't extend fertility beyond menopause is a bummer, but still super promising 
This is insane! They're basically trying to hack into human biology at this point 
. I mean, supplementing eggs with Shugoshin 1 is one thing, but what's next? Are we gonna start adding in some kind of genetic insurance policy to our embryos? It's like something out of a sci-fi movie 
. I'm really interested how this technology works and if it's safe for human use. The fact that it could potentially improve IVF success rates for older women is a huge deal, especially since millions of people around the world are struggling with infertility due to age 
. Of course, we need more research and trials to confirm the findings, but for now, I'm feeling pretty optimistic 
!
but if this breakthrough actually works then we're talking game changer 
! The fact that they can basically 'rejuvenate' eggs by reversing the age-related defect is mind blown 
and yeah it's a big deal because millions of women are struggling with declining fertility but let's also be real some of these scientists must've had a few too many coffee's to think this is the magic solution 
. This tech has the potential to give older women a real shot at getting pregnant, and that's a major win in my book 
. But I'm all for progress and I'm willing to give this a shot (pun intended 
) when the time comes. Fingers crossed this tech makes it into human trials soon 
but we gotta wait for further trials and confirmations before this tech hits the market.
so this breakthrough is like a breath of fresh air! experts say it's really promising, and who knows maybe one day u can conceive just 1 time through IVF instead of tryin multiple times