New Review Debunks Claim That Acetaminophen Use During Pregnancy Causes Autism and ADHD in Children
A major new review published in The Lancet Obstetrics, Gynecology & Women's Health has found that using acetaminophen as directed during pregnancy does not increase a child's risk of autism, attention-deficit/hyperactivity disorder (ADHD) or intellectual disability.
This conclusion holds up even when studies with more than five years of follow-up are included in the analysis.
Earlier observational studies have produced mixed results on this topic, with some suggesting that the medication may be associated with an increased risk of these conditions. However, the new meta-analysis, which reviewed results from about 60 studies, found no link to developmental disorders when expectant people used acetaminophen according to the label.
Acetaminophen is one of the most commonly used medications in pregnancy and is often recommended as a first option for pain or fever by doctors.
In sibling-comparison studies, which look at siblings born to the same mother when one pregnancy involved taking acetaminophen and another did not, exposure to the medication during pregnancy was not associated with autism spectrum disorder, ADHD, or any other intellectual disability.
The review may help explain why earlier observational studies appeared to show a possible link between acetaminophen use in pregnancy and developmental disorders.
People do not take acetaminophen randomly but for symptoms such as fever, infection, inflammation, or pain. These symptoms may also be linked to brain development of a fetus, making it possible to confuse the effects of the underlying condition with the effects of the medication.
Untreated fever has documented associations with serious pregnancy and fetal risks. The alternative pain medications β NSAIDs, opioids β carry their own pregnancy risks. Acetaminophen remains the safest option when medication is needed, according to experts.
The review highlights that studies linking acetaminophen use in pregnancy to autism or other conditions are vulnerable to misinterpretation and can be persuasive, especially when shared on social media.
In general, ACOG advises using acetaminophen when needed, following the label instructions, seeking medical guidance when appropriate, and paying attention to symptoms that prompt the drug's use.
A major new review published in The Lancet Obstetrics, Gynecology & Women's Health has found that using acetaminophen as directed during pregnancy does not increase a child's risk of autism, attention-deficit/hyperactivity disorder (ADHD) or intellectual disability.
This conclusion holds up even when studies with more than five years of follow-up are included in the analysis.
Earlier observational studies have produced mixed results on this topic, with some suggesting that the medication may be associated with an increased risk of these conditions. However, the new meta-analysis, which reviewed results from about 60 studies, found no link to developmental disorders when expectant people used acetaminophen according to the label.
Acetaminophen is one of the most commonly used medications in pregnancy and is often recommended as a first option for pain or fever by doctors.
In sibling-comparison studies, which look at siblings born to the same mother when one pregnancy involved taking acetaminophen and another did not, exposure to the medication during pregnancy was not associated with autism spectrum disorder, ADHD, or any other intellectual disability.
The review may help explain why earlier observational studies appeared to show a possible link between acetaminophen use in pregnancy and developmental disorders.
People do not take acetaminophen randomly but for symptoms such as fever, infection, inflammation, or pain. These symptoms may also be linked to brain development of a fetus, making it possible to confuse the effects of the underlying condition with the effects of the medication.
Untreated fever has documented associations with serious pregnancy and fetal risks. The alternative pain medications β NSAIDs, opioids β carry their own pregnancy risks. Acetaminophen remains the safest option when medication is needed, according to experts.
The review highlights that studies linking acetaminophen use in pregnancy to autism or other conditions are vulnerable to misinterpretation and can be persuasive, especially when shared on social media.
In general, ACOG advises using acetaminophen when needed, following the label instructions, seeking medical guidance when appropriate, and paying attention to symptoms that prompt the drug's use.