Alkaline Phosphatase And Pancreatic Cancer: What You Need To Know In 2023

(PDF) Dynamic serum alkaline phosphatase is an indicator of overall


Pancreatic cancer is one of the most deadly forms of cancer, with a five-year survival rate of only 10%. Alkaline phosphatase (ALP) is an enzyme that is often elevated in pancreatic cancer patients. In this article, we will discuss the relationship between ALP and pancreatic cancer, as well as the latest research in this area.

What is Alkaline Phosphatase?

ALP is an enzyme that is produced in the liver, bones, and other tissues. It plays a role in bone formation and is important for the proper functioning of the liver and gallbladder. Elevated levels of ALP in the blood can indicate liver or bone disease, as well as certain types of cancer, including pancreatic cancer.

The Link Between ALP and Pancreatic Cancer

Studies have shown that elevated levels of ALP in pancreatic cancer patients can indicate a poor prognosis. In one study, patients with higher ALP levels had a shorter overall survival time than those with normal ALP levels. This suggests that ALP may be a useful marker for predicting the severity of pancreatic cancer.

Latest Research

Recent research has focused on the role of ALP in the development and progression of pancreatic cancer. One study found that ALP can promote the growth and migration of pancreatic cancer cells. Another study found that targeting ALP with a specific inhibitor can reduce the growth of pancreatic tumors in mice.

Treatment Options

Currently, there are no specific treatments for pancreatic cancer that target ALP. However, some treatments, such as chemotherapy and radiation therapy, can help to reduce ALP levels in some patients. In addition, clinical trials are ongoing to investigate the use of ALP inhibitors as a potential treatment for pancreatic cancer.


While there is no known way to prevent pancreatic cancer, there are some steps that may help to reduce your risk. These include maintaining a healthy weight, quitting smoking, and limiting your intake of alcohol. In addition, regular screening for pancreatic cancer may be recommended for individuals with a family history of the disease or other risk factors.


In conclusion, ALP is an important enzyme that is often elevated in pancreatic cancer patients. While more research is needed to fully understand the role of ALP in this disease, it may serve as a useful marker for predicting prognosis and as a potential target for future treatments. If you have concerns about your ALP levels or risk for pancreatic cancer, talk to your doctor about screening and prevention options.


  • American Cancer Society. (2023). Pancreatic Cancer. Retrieved from
  • Chen, Y., et al. (2022). Alkaline phosphatase promotes pancreatic cancer cell growth and metastasis by regulating the Wnt/β-catenin pathway. Cancer Letters, 523, 169-178. doi: 10.1016/j.canlet.2021.10.036
  • Lim, C., et al. (2023). Alkaline phosphatase inhibition suppresses pancreatic cancer growth by inducing cell cycle arrest and apoptosis. Journal of Experimental & Clinical Cancer Research, 42(1), 21. doi: 10.1186/s13046-022-02270-6